February 8, 2012

Commentary

News Flash: Exceptional Genius Not Required…In Research, The Secret Is…

Cheree Cleghorn | June 11, 2010

The hazard of headlines is that the public can be left with the impression that genius discoveries are a daily event in medical research.

No.

This essay in The Lancet, a prestigious British medical journal, explains that many of the gains made in recent decades are not the aha! moments which would make a great movie.

The gains take patience, small steps—many of them—to improve survival rates.

In this excerpt, the writer shows how many children suffering from leukemia survive because of these patient, small steps made through clinical trials.

No new miracle drugs found. No dazzling discovery. Just plain hard work.

That is the truth of medical research, which does not make a great headline. It does not make for attention-getting testimony before a Congressional committee with the power to fund more research the disease du jour.

But this truth should offer us comfort.

We don’t have to wait for geniuses to have flashes of insight.

Hard work makes a huge difference in medicine.

This is great reading. The full text is offered free.

The Lancet

…”John Cade fortuitously noticed that lithium salts that calmed guineapigs could treat mania; Edward Jenner invented vaccination when he realised that milkmaids exposed to cowpox never got smallpox; Alexander Fleming discovered penicillin when he observed that one of his bacterial cultures was contaminated by a fungus that seemed to kill bacteria. Louis Pasteur once lectured, “In the fields of observation, chance favours only the prepared mind.” Such medical figures enjoyed lasting fame and gratitude; they all had found diamonds in the rough. These are the heroes of our medical legends, regularly featured in movies and newspapers. In short, myth-making medical stories are almost exclusively about the pursuit of serendipity—finding the miracle cure that has escaped notice from all others, and is ripe for the taking for the relentless doctor or patient who defies conventional practice.

“And yet, the truth is that the most important advances in health care today depend on painstaking, incremental steps instead of sudden revelations. A few years ago, I spoke with Stephen Sallan, the chief of staff of the Dana-Farber Cancer Institute in Boston. He explained that from the 1970s to the 1990s, the survival rates for children with leukaemia surged from less than 20% to over 80%. Was there a new miraculous drug discovered in the Amazon rainforests? No. Did a new genetic discovery occur? No. In fact, not a single new chemotherapeutic agent was introduced into the paediatric leukaemia protocol during that time. (Emphasis added)
“The heroes instead were those with patience who scratched out progress in less dramatic ways. In the course of over a dozen clinical trials, paediatric oncologists refined the use of doxorubicin and asparaginase, carefully tested the benefits of intrathecal administration of chemotherapeutics, and studied the optimum duration of therapy in children with apparent remission. Building on small improvements in survival, the doctors inched forward, with gradually better and better drug combinations, sites of injection, and dosages. Every few years, survival crawled ahead by a few percent. And after two decades, almost three in five children with leukaemia who used to die were instead living productive lives.” (Emphasis added)
Citation: The Lancet, Volume 375, Issue 9731, Pages 2068 – 2069, 12 June 2010

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